ANIN 50 Plus Tablet (Losartan Potassium 50 mg + Hydrochlorothiazide 12.5 mg), 20’s

Description

ANIN 50 Plus Tablet (Losartan Potassium 50 mg + Hydrochlorothiazide 12.5 mg), 20’s

INDICATION
It is indicated for the treatment of hypertension; for patients in whom combination therapy is
appropriate

DOSAGE AND ADMINISTRATION:
Hypertension
The usual starting dose of 50 mg Losartan Potassium and 12.5 mg of Hydrochlorothiazide is one
tablet daily once daily. For patients who do not respond adequately to one tablet the dosage may be
increased to 100 mg Losartan Potassium and 25 mg Hydrochlorothiazide tablet once daily. The
maximum dose is 100 mg Losartan Potassium and 25 mg Hydrochlorothiazide tablet once daily. In
general, the antihypertensive effect is attained within three weeks after initiation of therapy.
No initial dosage adjustment of 50 mg Losartan Potassium and 12.5 mg Hydrochlorothiazide is
necessary for elderly patients. But maximum dose of 100 mg Losartan Potassium and 25 mg of
Hydrochlorothiazide once daily dose should not be used as initial therapy in elderly patients.

Use in patients with renal impairment: The usual regimens of therapy with 50 mg Losartan
Potassium and 12.5 mg Hydrochlorothiazide may be followed as long as the patients creatinine
clearance is >30 ml/min. in patients with more severe renal impairment, loop diuretics are preferred to
thiazides. In that case, Hydrochlorothiazide is not recommended.

Use in patients with hepatic impairment: The combination of Losartan and Hydrochlorothiazide is
not recommended for titration in patients with hepatic impairment because the appropriate 25 mg
starting dose of Losartan Potassium cannot be given.

Severe Hypertension
The starting dose for the initial treatment of severe hypertension is one tablet of 50 mg Losartan
Potassium and 12.5 mg Hydrochlorothiazide once daily. For patients who do not respond adequately
to this dose after 2 to 4 weeks of therapy, the dosage may be increased to 100 mg Losartan
Potassium and 25 mg Hydrochlorothiazide once daily. The maximum dose is one tablet of once daily.
This combination drug may be administered with other antihypertensive agents. This drug may be
administered with or without food