Carvedilol is a non-cardio selective beta-blocker. It has vasodilating properties, which are attributed mainly to its blocking activity at alpha1 receptors; at higher doses calcium-channel blocking activity may contribute. It has also antioxidant properties. Carvedilol is reported to have intrinsic sympathomimetic activity and only weak membrane-stabilizing activity.
Carvedilol is used in the management of hypertension and angina pectoris, and as an adjunct to standard therapy in sympatomimetic heart failure. It is also used to reduce mortality in patients with left ventricular dysfunction after myocardial infarction.
DRUG OF CHOICE FOR:
• Hypertensive
• Angina
• Heart Failure
DOSAGE:
Hypertension: An initial dose of 6.25 mg is given twice daily, increased after one to two weeks 12.5 mg twice daily.
Angina: An initial dose of 12.5 mg is given twice daily, increased after two days to 25 mg twice daily.
Heart failure: The initial dose of 3.125 mg twice daily. If tolerated the dose should be doubled after two weeks to 6.25 mg twice daily.