Anti-Emetics / GIT Regulator

DEGUT 10 MG TABLET
Domperidone (as Maleate)


 

It is used as an antiemetic for the short term treatment of nausea and vomiting of various aetiologies including that associated with cancer therapy and nausea and vomiting associated with levodopa or bromocriptine therapy for parkinsonism. Also used for its prokinetic actions in dyspepsia.

DRUG OF CHOICE FOR:

• Dyspepsia
• Vomiting
• Acute Nausea

 

DOSAGE:

Degut should be taken 15-30 minutes before meal.

In case of acute nausea and vomiting the recommended oral dose for -
Adult: 10-20 mg (1-2 tablets) or 10 to 20 ml suspension every 4-8 hours.
Children: 0.2-0.4 mg/kg (2-4 ml susp./10 kg) body wt every 4-8 hours.

In case of functional dyspepsia
Adult: 10-20 mg (1-2 tablets) or 10 to 20 ml suspension 3 times daily before meal and at night.
Children: Not recommended.

For acute nausea, vomiting and functional dyspepsia, maximum period of treatment is 12 weeks.

 

 

 

Anti-Rhaumatic Agent and Anti-Cancer

METHOTRAX
(Methotrexate)




 

Trophoblastic neoplasms, breast cancer,psoriasis, rheumatoid arthritis with  leucovorin as adjunct to surgical resection or amputation of primary tumour  in patients with non-metastatic osteosarcoma, osteogenetic sarcoma; epidermoid cancers of the head and neck and lung cancer. Burkitt's lymphoma, advanced cases of Mycosis fungoides, advanced stages of lymphosarcoma and autoimmune and collagen vascular diseases.

DRUG OF CHOICE FOR:

• Arthritis Hand
• Arthritis Feet
• Arthritis Knee
• Trophoblastic neoplasms
• Non-metastatic osteosarcoma

 

DOSAGE:

In the treatment of rheumatoid arthritis: By mouth, 7.5 mg once weekly as a single dose or divided into 3 doses of 2.5 mg given at intervals of 12 hours, adjusted according to response; maximum total weekly dose 20 mg.

Leukemia in children (maintenance): By mouth, 15 mg/m2 body surface weekly in combination with other drugs.

Maintenance therapy of acute lymphoblastic leukemia: A common dose of 15-30 mg/m2 body surface, once or twice weekly by mouth with other agents.

Choriocarcinoma: Treated with doses of 15-30 mg daily by mouth for 5 days at intervals of 1-2 weeks for 3-5 courses. Doses of 10-16 mg/m2 have also been employed in the treatment of breast cancer, often in combination with Cyclophosmamide & 
Fluorouracil.

In the treatment of Psoriasis: Single weekly doses of 10-25 mg may be given by mouth, adjusted according to response.

 

Non-Steroidal Anti-Inflammatory

KET 10 MG TABLET
KETOROLAC TROMETAMOL


Ket (Ketorolac trometamol) is indicated for the short-term ( ≤ 5 days) management of moderately severe acute pain that requires analgesia at the opioid level, usually in a postoperative setting. Therapy should always be initiated with IV or IM dosing of ketorolac trometamol, and Ket (Ketorolac trometamol) is to be used only as continuation treatment, if necessary. .

DRUG OF CHOICE FOR:

• Acute Pain
• Postoperative Pain
• Chronic Pain
• Tooth Pain
• Pain

DOSAGE:

Adult (Under 65 years of age):
The usual oral dose of Ketorolac Trometamol is 10 mg every 4 to 6 hours, as required. Doses exceeding 40 mg per day are not recommended.

Elderly (65 years of age and older):
The usual oral dose of Ketorolac Trometamol in the elderly is 10 mg every 4 to 8 hours. Daily doses of 30 mg to 40 mg per day should not be exceeded. The use of Ketorolac Trometamol tablet is recommended for the shortest possible time.

The total duration of Ketorolac Trometamol administration should not exceed 5 days because adverse effects may increase with prolonged usage.





NASIDA 10 MG TABLET
DICLOFENAC SODIUM

Used for the relief of pain and inflammation in various conditions: musculoskeletal and joint disorders such as rheumatoid arthritis, osteoarthritis and ankylosing spondylitis; peri-articular disorders such as bursitis and tendonitis; soft-tissue disorders such as sprains and strains; and other painful condition such as renal colic, acute gout, dysmenorrhoea, migraine and after some surgical procedures.

DRUG OF CHOICE FOR:

• Acute Pain
• Postoperative Pain
• Chronic Pain
• Tooth Pain
• Pain

DOSAGE:

Nasida Tablet
• Adult dose: The usual recommended oral dose is 75-150 mg daily in 2 to 3 divided doses up to a maximum of 200 mg daily, preferably with food.
• In osteoarthritis: The recommended dose is 100-150 mg daily in 2 to 3 divided doses.
• In rheumatoid arthritis: the recommended dose is 150-200 mg daily in 3 to 4 divided doses.
• In ankylosing spondylitis: The usual recommended dose is 100-125 mg daily in   4-5 divided doses
• In primary dysmennorhea: The usual recommended daily dose is 50-150 mg; a dosage of 50-100 mg is to be used initially and increased to a maximum of 200 mg daily divided into 2-3 doses. In long term treatment the doses should be reduced.
• Paediatric dose (over 1 year): In juvenile arthritis, orally 1-3 g/kg of body weight daily, in 2-3 divided doses.

Nasida SR Capsule
• One capsule daily, preferably at meal time or as directed by the physician.

 





 

Skeletal Muscle Relaxant

LIOSAL
Domperidone (as Maleate)




 

• Baclofen is useful for the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity.
• Patients should have reversible spasticity so that baclofen treatment will aid in restoring residual function.
• Baclofen may also be of some value in patients with spinal cord injuries and other spinal cord diseases.
• Baclofen is not indicated in the treatment of skeletal muscle spasm resulting from rheumatic disorders.
• The efficacy of baclofen tablets in stroke, cerebral palsy, and Parkinson’s disease has not been established and, therefore, it is not recommended for these conditions.

 

DRUG OF CHOICE FOR:

• Low Back Pain
• Spinal Cord Injury
• Toe Flexion (Spasm)

DOSAGE:

Baclofen is given orally in divided doses, preferably with or after food or milk. The initial dose of baclofen is 5 mg three times daily for 3 days, increased to 10 mg three times daily for 3 days, then in similar increments and intervals until either a dose of 20 mg three times daily is reached or until desired therapeutic effect is obtained.