INDICATION
Baclofen (Liosal) is a prescription medicine used to treat the symptoms of spasticity
from multiple sclerosis, in particularity for the relief of spasm and concomitant pain
clonus and muscular rigidity. Baclofen (Liosal) is also indicated for the treatment of
Dystonia, Spasticity associated with cerebral palsy, And trigeminal neuralgia.
DOSAGE & ADMINISTRATION
Baclofen (Liosal) is given orally in divided doses, preferably with or after food or
milk. The initial dose of baclofen is 5 mg three times daily for 3 days, increased to 10
mg three times daily for 3 days, then in similar increments and intervals until either a
dose of 20 mg three times daily is reached or until the desired therapeutic effect is
obtained. Higher doses have been used. Doses of more than 80 to 100 mg daily are
not generally recommended although doses of up to 150 mg daily have been given
to carefully to supervised patients.
In the UK a dosage range of 0.75 to 2 mg/kg daily has been used for children; in
children over 10 years a maximum daily dosage of 2.5 mg/kg may be given. It is
usual to start with a low dose of 2.5 mg given four times daily, increased cautiously
about 3 days until the desired therapeutic effect is obtained. The recommended daily
maintenance doses are: 12 months to 2 years, 10 to 20 mg; 2 to 6 years, 20 to 30
mg; 6 to 10 years, 30 to 60 mg.